Biodiesel was produced by transesterification of waste olive oil with methanol and Novozym®435. The effect of the molar ratio of methanol to triolein, mode of methanol addition, reaction temperature, and mixing speed on biodiesel yield was determined. The effect of different acyl acceptors and/or solvents on biodiesel yield was also evaluated. Finally, the efficacy of Novozym®435 was determined by reusing the enzyme after washing it with a solvent.

This paper presents a new solution to the well-known exchange paradox, or what is sometimes referred to as the two-envelope paradox. Many recent commentators have analyzed the paradox in terms of the agent’s biased concern for the contents of his own arbitrarily chosen envelope, claiming that such bias violates the manifest symmetry of the situation. Such analyses, however, fail to make clear exactly how the symmetry of the situation is violated by the agent’s hypothetical conclusion that he ought to switch (...) envelopes on the assumption that his own envelope contains some specific amount of money. In this paper, I offer an explanation of this fact based on the idea that the agent’s deliberations are not only constrained by the epistemic symmetry reflected in the agent’s uniform ignorance as to the contents of the two envelopes, but also by a deeper methodological symmetry that manifests itself in the intuition that the two envelopes constitute equally legitimate sources of potential information. I interpret this intuition as implying that the agent’s final decision should reflect a point of rational equilibrium arrived at through an iterated process of counterfactual self-reflection, whereby the agent takes account of what he would have thought had he instead chosen the other envelope. I provide a formal model of this method of counterfactual self-reflection and show, in particular, that it cannot issue in the paradoxical conclusion that the agent ought to switch regardless of how much money is in his envelope. In this way, by correcting for the bias in the agent’s reasoning, the paradox is resolved. (shrink)

One well-known objection to the principle of maximum entropy is the so-called Judy Benjamin problem, first introduced by van Fraassen. The problem turns on the apparently puzzling fact that, on the basis of information relating an event’s conditional probability, the maximum entropy distribution will almost always assign to the event conditionalized on a probability strictly less than that assigned to it by the uniform distribution. In this article, I present an analysis of the Judy Benjamin problem that can help to (...) make sense of this seemingly odd feature of maximum entropy inference. My analysis is based on the claim that, in applying the principle of maximum entropy, Judy Benjamin is not acting out of a concern to maximize uncertainty in the face of new evidence, but is rather exercising a certain brand of epistemic charity towards her informant. This epistemic charity takes the form of an assumption on the part of Judy Benjamin that her informant’s evidential report leaves out no relevant information. Such a reconceptualization of the motives underlying Judy Benjamin’s appeal to the principle of maximum entropy can help to further our understanding of the true epistemological grounds of this principle and correct a common misapprehension regarding its relationship to the principle of insufficient reason. 1Introduction2The Principle of Maximum Entropy3An Apologia for Judy Benjamin4Conclusion: Entropy and Insufficient Reason. (shrink)

In this paper, we provide a Bayesian analysis of the well-known surprise exam paradox. Central to our analysis is a probabilistic account of what it means for the student to accept the teacher's announcement that he will receive a surprise exam. According to this account, the student can be said to have accepted the teacher's announcement provided he adopts a subjective probability distribution relative to which he expects to receive the exam on a day on which he expects not to (...) receive it. We show that as long as expectation is not equated with subjective certainty there will be contexts in which it is possible for the student to accept the teacher's announcement, in this sense. In addition, we show how a Bayesian modeling of the scenario can yield plausible explanations of the following three intuitive claims: (1) the teacher's announcement becomes easier to accept the more days there are in class; (2) a strict interpretation of the teacher's announcement does not provide the student with any categorical information as to the date of the exam; and (3) the teacher's announcement contains less information about the date of the exam the more days there are in class. To conclude, we show how the surprise exam paradox can be seen as one among the larger class of paradoxes of doxastic fallibilism, foremost among which is the paradox of the preface. (shrink)

The technique of minimizing information (infomin) has been commonly employed as a general method for both choosing and updating a subjective probability function. We argue that, in a wide class of cases, the use of infomin methods fails to cohere with our standard conception of rational degrees of belief. We introduce the notion of a deceptive updating method and argue that non-deceptiveness is a necessary condition for rational coherence. Infomin has been criticized on the grounds that there are no higher (...) order probabilities that ‘support’ it, but the appeal to higher order probabilities is a substantial assumption that some might reject. Our elementary arguments from deceptiveness do not rely on this assumption. While deceptiveness implies lack of higher order support, the converse does not, in general, hold, which indicates that deceptiveness is a more objectionable property. We offer a new proof of the claim that infomin updating of any strictly-positive prior with respect to conditional-probability constraints is deceptive. In the case of expected-value constraints, infomin updating of the uniform prior is deceptive for some random variables but not for others. We establish both a necessary condition and a sufficient condition (which extends the scope of the phenomenon beyond cases previously considered) for deceptiveness in this setting. Along the way, we clarify the relation which obtains between the strong notion of higher order support, in which the higher order probability is defined over the full space of first order probabilities, and the apparently weaker notion, in which it is defined over some smaller parameter space. We show that under certain natural assumptions, the two are equivalent. Finally, we offer an interpretation of Jaynes, according to which his own appeal to infomin methods avoids the incoherencies discussed in this paper. (shrink)

Japan has more robots than any other country with robots contributing to many areas of society, including manufacturing, healthcare, and entertainment. However, few studies have examined Japanese attitudes toward robots, and none has used implicit measures. This study compares attitudes among the faculty of a US and a Japanese university. Although the Japanese faculty reported many more experiences with robots, implicit measures indicated both faculties had more pleasant associations with humans. In addition, although the US faculty reported people were more (...) threatening than robots, implicit measures indicated both faculties associated weapons more strongly with robots than with humans. Despite the media’s hype about Japan’s robot ‘craze,’ response similarities suggest factors other than attitude better explain robot adoption. These include differences in history and religion, personal and human identity, economic structure, professional specialization, and government policy. Japanese robotics offers a unique reference from which other nations may learn. (shrink)

Gene expression is an inherently complex process and errors often occur during the transcription and processing of mRNAs. Several surveillance mechanisms have evolved to check the fidelity at each step of mRNA manufacture. Two recent reports describe the identification of a novel pathway in eukaryotes that recognizes and degrades mRNAs that lack a stop codon.1,2 The non‐stop decay mechanism releases ribosomes stalled at the 3′ end of a mRNA and stimulates the exosome to rapidly degrade the transcript. BioEssays 24:785–788, 2002. (...) © 2002 Wiley Periodicals, Inc. (shrink)

We argue that in spite of their apparent dissimilarity, the methodologies employed in the a priori and a posteriori assessment of probabilities can both be justified by appeal to a single principle of inductive reasoning, viz., the principle of symmetry. The difference between these two methodologies consists in the way in which information about the single-trial probabilities in a repeatable chance process is extracted from the constraints imposed by this principle. In the case of a posteriori reasoning, these constraints inform (...) the analysis by fixing an a posteriori determinant of the probabilities, whereas, in the case of a priori reasoning, they imply certain claims which then serve as the basis for subsequent probabilistic deductions. In a given context of inquiry, the particular form which a priori or a posteriori reason may take depends, in large part, on the strength of the underlying symmetry assumed: the stronger the symmetry, the more information can be acquired a priori and the less information about the long-run behavior of the process is needed for an a posteriori assessment of the probabilities. In the context of this framework, frequency-based reasoning emerges as a limiting case of a posteriori reasoning, and reasoning about simple games of chance, as a limiting case of a priori reasoning. Between these two extremes, both a priori and a posteriori reasoning can take a variety of intermediate forms. (shrink)

Judgments of symmetry lay at the heart of the classical theory of probability. It was by direct appeal to the symmetries exhibited by the processes underlying simple games of chance that the earliest theorists of probability were able to justify the initial assumptions of equiprobability which allowed them to compute the probabilities of more complex events using combinatorial methods, i.e., by simply counting cases. Nevertheless, in spite of the role that symmetry played in the earliest writings on the subject, in (...) light of the fact it is only in highly contrived settings that a direct appeal to symmetries can suffice to determine the probabilities of events, many philosophers have been led to conclude that the concept of symmetry itself has, at best, a limited role to play in a general theory of probability. In this essay, I argue that this view of the matter is mistaken, and that judgments of symmetry, in fact, have an indispensible role to play in all probabilistic reasoning. In chapter 1, I provide a detailed account of symmetry-based reasoning and argue against the view that the judgments of relevance on which such reasoning is based must be construed in subjective terms if symmetry-based reasoning is to be applied to deterministic processes. In chapter 2, I argue that the two most plausible proposals for how to avoid an appeal to symmetry in the assignment of probabilities (viz., those which are based on a priori principles of epistemic conservatism or the observed frequencies of events) must themselves rely on implicit assumptions of symmetry if they are to defend themselves against the charges of incoherency and arbitrariness. In chapter 3, I consider a decision-theoretic example of symmetry-based reasoning, in which the appeal to symmetry arises in the context of an agent's choice of a deliberative methodology. In this context, the principle of symmetry amounts to the requirement that the agent avoid adopting a biased deliberative methodology, i.e., one which treats two equally legitimate sources of information differently. In the specific context of the exchange paradox, I propose an account of how biased information is to be handled, which, despite suffering from some important defects, does, I believe, capture some of our general intuitions about how a rational agent ought to adjust his expectations to correct for the effects of bias. (shrink)

Greek antiquity saw the development of two distinct systems of logic: Aristotle’s theory of the categorical syllogism and the Stoic theory of the hypothetical syllogism. Some ancient logicians argued that hypothetical syllogistic is more fundamental than categorical syllogistic on the grounds that the latter relies on modes of propositional reasoning such asreductio ad absurdum. Peripatetic logicians, by contrast, sought to establish the priority of categorical over hypothetical syllogistic by reducing various modes of propositional reasoning to categorical form. In the 17th (...) century, this Peripatetic program of reducing hypothetical to categorical logic was championed by Gottfried Wilhelm Leibniz. In an essay titledSpecimina calculi rationalis, Leibniz develops a theory of propositional terms that allows him to derive the rule ofreductio ad absurdumin a purely categorical calculus in which every proposition is of the formA is B. We reconstruct Leibniz’s categorical calculus and show that it is strong enough to establish not only the rule ofreductio ad absurdum, but all the laws of classical propositional logic. Moreover, we show that the propositional logic generated by the nonmonotonic variant of Leibniz’s categorical calculus is a natural system of relevance logic known as RMI$_{{}_ \to ^\neg }$. (shrink)

Corporate governance has come to be recognised as a cornerstone of economic reforms seeking to promote stability and growth in developing countries. The Asian crisis of the 1997 was viewed as having roots in poor governance and hence national governments as well as international organisations have sought to promote a strengthening of governance mechanisms. This article investigates governance reforms in India over the last decade. The paper reviews changes in Indian governance codes that indicate a preference of adoption of Anglo-American (...) governance models. A survey of ownership structures of Indian listed companies reveals a mixture of governance mechanisms and a persistence of the "business house model" of governance. The paper concludes that despite external pressures towards an "Anglo-Americanisation" of governance practice, the outcomes thus far reveal the emergence of a diversity of governance mechanisms arising in a path-dependent fashion. (shrink)

Chromatin structure and dynamics regulate key cellular processes such as DNA replication, transcription, repair, remodeling, and gene expression, wherein different protein factors interact with the nucleosomes. In these events, DNA and RNA polymerases, chromatin remodeling enzymes and transcription factors interact with nucleosomes, either in a DNA‐sequence‐specific manner and/or by recognizing different structural features on the nucleosome. The molecular details of the recognition of a nucleosome by different viral proteins, remodeling enzymes, histone post‐translational modifiers, and RNA polymerase II, have been explored (...) in the recent past. The present review puts forth critical insights into the basic mechanisms of nucleosome recognition by the various protein factors and the role of distinct surface epitopes on a nucleosome. These determinants of the underlying specificity include features such as the acidic patch, arginine anchor, histone post‐translational modifications, core DNA, DNA lesions, and linker DNA. (shrink)

TheGenerales Inquisitiones de Analysi Notionum et Veritatumis Leibniz’s most substantive work in the area of logic. Leibniz’s central aim in this treatise is to develop a symbolic calculus of terms that is capable of underwriting all valid modes of syllogistic and propositional reasoning. The present paper provides a systematic reconstruction of the calculus developed by Leibniz in theGenerales Inquisitiones. We investigate the most significant logical features of this calculus and prove that it is both sound and complete with respect to (...) a simple class of enriched Boolean algebras which we call auto-Boolean algebras. Moreover, we show that Leibniz’s calculus can reproduce all the laws of classical propositional logic, thus allowing Leibniz to achieve his goal of reducing propositional reasoning to algebraic reasoning about terms. (shrink)

In his Philosophical Inquiry concerning Human Liberty (1717), the English deist Anthony Collins proposed a complete determinist account of the human mind and action, partly inspired by his mentor Locke, but also by elements from Bayle, Leibniz and other Continental sources. It is a determinism which does not neglect the question of the specific status of the mind but rather seeks to provide a causal account of mental activity and volition in particular; it is a ‘volitional determinism’. Some decades later, (...) Diderot articulates a very similar determinism, which seeks to recognize the existence of “causes proper to man” (as he says in the Réfutation d’Helvétius). The difference with Collins is that now biological factors are being taken into account. Obviously both the ‘volitional’ and the ‘biological’ forms of determinism are noteworthy inasmuch as they change our picture of the nature of determinism itself, but my interest here is to compare these two determinist arguments, both of which are broadly Spinozist in nature – and as such belong to what Jonathan Israel called in his recent book “the radical Enlightenment,” i.e. a kind of underground Enlightenment constituted by Spinozism – and to see how Collins’ specifically psychological vision and Diderot’s specifically biological vision correspond to their two separate national contexts: determinism in France in the mid-1750s was a much more medico-biological affair than English determinism, which appears to be on a ‘path’ leading to Mill and associationist psychology. (shrink)

J. Willard Gibbs derived the following equation to quantify the maximum work possible for a chemical reaction$${\text{Maximum work }} = \, - \Delta {\text{G}}_{{{\text{rxn}}}} = \, - \left( {\Delta {\text{H}}_{{{\text{rxn}}}} {-}{\text{ T}}\Delta {\text{S}}_{{{\text{rxn}}}} } \right) {\text{ constant T}},{\text{P}}$$ Maximum work = - Δ G rxn = - Δ H rxn - T Δ S rxn constant T, P ∆Hrxn is the enthalpy change of reaction as measured in a reaction calorimeter and ∆Grxn the change in Gibbs energy as measured, if (...) feasible, in an electrochemical cell by the voltage across the two half-cells. To Gibbs, reaction spontaneity corresponds to negative values of ∆Grxn. But what is T∆Srxn, absolute temperature times the change in entropy? Gibbs stated that this term quantifies the heating/cooling required to maintain constant temperature in an electrochemical cell. Seeking a deeper explanation than this, one involving the behaviors of atoms and molecules that cause these thermodynamic phenomena, I employed an “atoms first” approach to decipher the physical underpinning of T∆Srxn and, in so doing, developed the hypothesis that this term quantifies the change in “structural energy” of the system during a chemical reaction. This hypothesis now challenges me to similarly explain the physical underpinning of the Gibbs–Helmholtz equation$${\text{d}}\left( {\Delta {\text{G}}_{{{\text{rxn}}}} } \right)/{\text{dT}} = - \Delta {\text{S}}_{{{\text{rxn}}}} \left( {\text{constant P}} \right)$$ d Δ G rxn / dT = - Δ S rxn constant P While this equation illustrates a relationship between ∆Grxn and ∆Srxn, I don’t understand how this is so, especially since orbital electron energies that I hypothesize are responsible for ∆Grxn are not directly involved in the entropy determination of atoms and molecules that are responsible for ∆Srxn. I write this paper to both share my progress and also to seek help from any who can clarify this for me. (shrink)

Experimental Phenomena of Consciousness is the definitive collection of consciousness phenomena in which awareness emerges as an experimental variable. With its comprehensive yet succinct entries, arranged alphabetically, this dictionary will be a valuable reference tool for libraries and researchers at all levels in psychology, neuroscience, and philosophy, who are investigating consciousness, cognition, perception, and attention. It will also be an important addition to the reading lists of courses on consciousness and cognition. Most entries include illustrations and a list of references (...) where a more thorough treatment of the topic can be found. The text is supported by a web page that provides dynamic illustrations and other supplemental material. As the first reference book on the topic, Experimental Phenomena of Consciousness will be a valuable tool for undergraduates, graduate students, professional researchers, and anyone who has an interest in the subject of consciousness. (shrink)

The most pressing issues of the twenty-first century—climate change and persistent hunger in a world of food surpluses, to name only two—are not problems that can be solved from within individual disciplines, nation-states, or cultural perspectives. They are predicaments that can only be resolved by generating sustained and globally robust coordination across value systems. The scale of the problems and necessity for coordinated global solutions signal a world historical transit as momentous as the Industrial Revolution: a transition from the predominance (...) of technical knowledge to that of ethical deliberation. This volume brings together leading thinkers from around the world to deliberate on how best to correlate worth (value) with what is worthwhile (values), pairing human prosperity with personal, environmental, and spiritual flourishing in a world of differing visions of what constitutes a moral life. Especially in the aftermath of what is now being called the Great Recession, awareness has mounted of the imperative to question the modern divorce of economics from ethics. While the domains of economics and ethics were from antiquity through at least the eighteenth century understood in many cultures to be coterminous and mutually entailing, the modern assumption has been that the goal of maximizing human prosperity and the aim of justly enhancing our lives as persons and as communities were functionally and practically distinct. Working from a wide array of perspectives, the contributors to this volume offer a set of challenges to the assumed independence of the quantitative and qualitative dimensions of human and planetary well-being. Reflecting on the complex interrelationship among economics, justice, and equity, the book resists "one size fits all" approaches and struggles to revitalize the marriage of economics and ethics by activating cultural differences as the basis of mutual contribution to shared human flourishing. The publication of this important collection will stimulate or extend critical debates among scholars and students working in a number of disciplines in the social sciences and humanities, including philosophy, history, environmental studies, economics, and law. Contributors: Roger T. Ames, James Behuniak Jr., Steve Bein, Nalini Bhushan, Purushottama Bilimoria, Steven Burik, Amita Chatterjee, Baoyan Cheng, Gordon Davis, Jay L. Garfield, Steven F. Geisz, Peter D. Hershock, Larry A. Hickman, Kathleen M. Higgins, Heidi M. Hurd, Thomas P. Kasulis, Workineh Kelbessa, Lori Keleher, Oliver Leaman, James McRae, Jin Y. Park, James Peterman, Naoko Saito, May Sim, Robert Smid, Paul Standish, Kenneth W. Stikkers, Karsten J. Struhl, Meera Sushila Viswanathan, Wu Shiu- Ching, Xu Di, T. Yamauchi, Yang Liuxin. (shrink)

The present study sought to clarify the impact of executive and social functioning on challenging behavior and the downstream influence of challenging behavior on quality of life and functioning in a large transdiagnostic sample. Understanding these relationships is crucial for developing and designing tailored intervention strategies. In a cross-sectional study, parent informants of 2,004 children completed measures of executive and social functioning, challenging behavior, child and family quality of life, and reported on functional impacts of challenging behavior. Using structural (path) (...) modeling, analyses evaluated the associations between executive and social functioning, including emotion regulation and risk avoidance, with overall and specific types of challenging behavior. Structural models also examined the influence of challenging behavior on child and family quality of life, including measures of the immediate and extended environment, and functional impacts on the parent/child as well as interactions with the medical/legal systems. Finally, mediational models explored the direct and indirect effects of executive and social functioning on quality of life and impact measures via challenging behavior. Results indicated that executive functioning accounts for substantial variance (R2 = 0.47) in challenging behavior. In turn, challenging behavior accounts for substantial variance in child and family quality of life (R2 = 0.36) and parent/child impacts (R2 = 0.31). Exploratory mediational models identified direct effects from executive and social functioning measures on quality of life and functional impacts and indirect effects for executive functioning via challenging behavior. These findings support the development of new intervention strategies and suggest the need to measure executive functioning when assessing and tailoring the treatment of challenging behavior in clinical practice. (shrink)